3-Hydroxyazetidine Hydrochloride CAS 18621-18-6 Baricitinib Intermediate Purity >98.5% (HPLC) Factory

Short Description:

Chemical Name: 3-Hydroxyazetidine Hydrochloride

CAS: 18621-18-6

Purity: >98.5% (HPLC)

Appearance: White to Tan Solid Powder

Intermediate of Baricitinib (CAS: 1187594-09-7)

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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18621-18-6 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 3-Hydroxyazetidine Hydrochloride (CAS: 18621-18-6) with high and stable quality control, an important intermediate of Baricitinib (CAS: 1187594-09-7).
Ruifu Chemical has been supplying pharmaceutical intermediates and APIs more than 15 years. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available.
Purchase 3-Hydroxyazetidine Hydrochloride and other Baricitinib intermediates, Please contact us by e-mail: alvin@ruifuchem.com for quotation requests. Please provide quantity, purity, and any other specific requirements.

Intermediates of Baricitinib (CAS: 1187594-09-7):

Baricitinib API	CAS 1187594-09-7
1-Boc-3-Azetidinone	CAS 398489-26-4
3-Hydroxyazetidine Hydrochloride	CAS 18621-18-6
1-Boc-3-(Cyanomethylene)azetidine	CAS 1153949-11-1
2-[1-(Ethylsulfonyl)azetidin-3-ylidene]acetonitrile	CAS 1187595-85-2
2-(Azetidin-3-ylidene)acetonitrile Hydrochloride	CAS 1314910-43-4
1-(1-Ethoxyethyl)-1H-Pyrazole-4-Boronic Acid Pinacol Ester	CAS 1029716-44-6
4-(1H-Pyrazol-4-yl)-7-[[2-(Trimethylsilyl)ethoxy]methyl]-7H-Pyrrolo[2,3-d]pyrimidine	CAS 941685-27-4

18621-18-6 - Chemical Properties:

Chemical Name	3-Hydroxyazetidine Hydrochloride
Synonyms	3-Hydroxyazetidine HCl; 3-(Hydroxy)azetidine Hydrochloride; 3-Azetidinol Hydrochloride; Azetidin-3-Ol Hydrochloride; Azetidin-3-Ol HCl; 3-Hydroxyazacyclobutane Hydrochloride
Stock Status	In Stock, Commercial Production
CAS Number	18621-18-6
Molecular Formula	C3H7NO·HCl
Molecular Weight	109.55 g/mol
Melting Point	87.0 to 92.0℃
Store Under Inert Gas	Store Under Inert Gas
Sensitive	Hygroscopic. Ambient Temperatures
Solubility	Soluble in Water, DMSO, Methanol
COA & MSDS	Available
Origin of Product	Shanghai, China
Product Categories	Pharmaceutical Intermediates
Brand	Ruifu Chemical

18621-18-6 - Specifications:

Items	Specifications	Results
Appearance	White to Tan Solid Powder	White Solid Powder
Melting Point	87.0~92.0℃	89.0~91.0℃
Water by Karl Fischer	<1.00%	0.32%
Related Substances
Any Single Impurity	<1.00%	<1.00%
Total Impurities	<1.50%	0.39%
3-Hydroxyazetidine HCl Purity	>98.5% (HPLC)	99.61%
1H NMR Spectrum	Conforms to Structure	Conforms
Conclusion	The product has been tested and complies with the given specifications
Usage	Intermediate of Baricitinib (CAS: 1187594-09-7)

18621-18-6 - Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Hygroscopic. Store under inert gas. Keep the container tightly closed and store in a cool, dry, well-ventilated warehouse. Keep away from sunshine; avoid fire and heat sources. Store away from water/ moisture, oxidizing agents.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.

18621-18-6 - Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

18621-18-6 - FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

18621-18-6 - Risk and Safety:

Risk Codes R36/37/38 - Irritating to eyes, respiratory system and skin.
R41 - Risk of serious damage to eyes
R37/38 - Irritating to respiratory system and skin.
R22 - Harmful if swallowed
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs UN1759
WGK Germany 3
HS Code 2933990099
Hazard Note Harmful/Corrosive
Hazard Class IRRITANT

18621-18-6 - Application:

3-Hydroxyazetidine Hydrochloride (CAS: 18621-18-6) is an important intermediate in the synthesis of Baricitinib (CAS: 1187594-09-7), and Baricitinib is finally obtained through multi-step reactions. Baricitinib has been approved in the European Union, as a single agent or in combination with Methotrexate, for moderately to severely active rheumatoid patients with insufficient or intolerable response to one or more antirheumatic drugs (DMARDs). Treatment of adults with arthritis.