Lapatinib Intermediate CAS 231278-84-5 Purity >98.0% (HPLC)

Short Description:

5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde

CAS: 231278-84-5

Purity: >98.0% (HPLC)

Appearance: Pale Yellow to Yellow Solid Powder

Intermediate of API (CAS 388082-77-7)

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Product Detail

Product Tags

Lapatinib Intermediates:

Lapatinib Base	CAS 231277-92-2
Lapatinib Ditosylate Monohydrate	CAS 388082-78-8
Sodium Methanesulfinate	CAS 20277-69-4
3-Chloro-4-(3-Fluorobenzyloxy)aniline	CAS 202197-26-0
2-Aminoethyl Methyl Sulfone Hydrochloride	CAS 104458-24-4
4-Chloro-6-Iodoquinazoline	CAS 98556-31-1
6-Iodo-4-Hydroxyquinazoline	CAS 16064-08-7
5-Formyl-2-Furanboronic Acid	CAS 27329-70-0
5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde	CAS 231278-84-5

Chemical Properties:

Chemical Name	5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde
Synonyms	Lapatinib Intermediate 3; 5-[4-[[3-Chloro-4-[(3-Fluorophenyl)methoxy]phenyl]amino]-6-Quinazolinyl]-2-Furancarboxaldehyde; 5-[4-((3-Chloro-4-((3-Fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-Furaldehyde
CAS Number	231278-84-5
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C26H17ClFN3O3
Molecular Weight	473.90
Melting Point	225.0 to 235.0℃
Density	1.407±0.06 g/cm3
Refractive Index	1.694
COA & MSDS	Available
Origin	Shanghai, China
Brand	Ruifu Chemical

Specifications:

Item	Specifications
Appearance	Pale Yellow to Yellow Solid Powder
Purity / Analysis Method	>98.0% (HPLC)
Melting Point	225.0~235.0℃
Loss on Drying	<1.00%
Residue on Ignition	<0.50%
Total Impurities	<2.00%
Heavy Metals (as Pb)	<20ppm
Test Standard	Enterprise Standard
Usage	Intermediate of API (CAS 388082-77-7)

Package & Storage:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement

Storage Condition: Store in sealed containers at cool and dry place; Protect from light and moisture

Advantages:

FAQ:

231278-84-5 - Application:

5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde (CAS: 231278-84-5) is an intermediate of API (CAS 388082-77-7). (CAS 388082-77-7) is a drug targeting breast cancer developed by British GlaxoSmithKline Co. It is a tyrosine kinase inhibitor which can effectively inhibit the tyrosine kinase activity of human epidermal growth factor receptors 1 and 2 (ErbB1, ErbB2). It can uniquely act in a variety of ways, ensuring that breast cancer cells cannot receive growth signals. It inhibits intracellular EGFR (ErbB-1) and HER2 (ErbB-2) ATP sites, preventing tumor cell phosphorylation and activation, blocking down-regulation signals through the homogeneity and heterogeneity of EGFR (ErbB-1) and HER2 (ErbB-1) dimerization.