Ramelteon Acrylonitrile CAS 196597-79-2 Ramelteon Intermediate Purity >98.0% (HPLC)
Shanghai Ruifu Chemical is the leading supplier of Ramelteon Acrylonitrile (CAS: 196597-79-2) with high quality, mainly used as an intermediates of Ramelteon (CAS: 196597-26-9).
Ruifu Chemical has been supplying pharmaceutical intermediates and API (active pharmaceutical ingredient) more than 15 years, can provide worldwide delivery, competitive price, excellent service.
Purchase Ramelteon Acrylonitrile or other intermediates of Ramelteon, please e-mail: alvin@ruifuchem.com
| Chemical Name | (E)-(1,6,7,8-Tetrahydro-2H-Indeno[5,4-b]furan-8-ylidene)acetonitrile |
| Synonyms | Ramelteon Acrylonitrile; Ramelteon Impurity 6; Ramelteon Impurity B; Ramelteon Cyano Impurity; (E)-2-(6,7-Dihydro-1H-Indeno[5,4-b]furan-8(2H)-ylidene)acetonitrile; (2E)-2-(1,2,6,7-Tetrahydrocyclopenta[e][1]benzofuran-8-ylidene)acetonitrile; (1,2,6,7-Tetrahydro-3-oxa-as-indacen-8-ylidene)-acetonitrile |
| CAS Number | 196597-79-2 |
| Stock Status | In Stock, Production Scale Up to Tons |
| Molecular Formula | C13H11NO |
| Molecular Weight | 197.23 |
| Melting Point | 146.0~151.0℃ |
| Boiling Point | 392.1±21.0℃ at 760 mmHg |
| Density | 1.321±0.06 g/cm3 |
| Solubility | 10 mM in DMSO |
| Storage Condition | 2-8℃ |
| Shelf Life | 24 Months When Properly Stored |
| COA & MSDS | Available |
| Place of Origin | Shanghai, China |
| Product Categories | Pharmaceutical Intermediates |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White to Yellow Solid Powder |
| Purity / Analysis Method | >98.0% (HPLC) |
| Loss on Drying | <1.00% |
| Total Impurities | <2.00% |
| 1 H NMR Spectrum | Consistent With Structure |
| Test Standard | Enterprise Standard |
| Usage | Intermediate of Ramelteon (CAS: 196597-26-9) |
Package: Bottle, aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2-8℃) and well-ventilated warehouse away from incompatible substances. Prevent direct sunlight; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by sea, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
(E)-(1,6,7,8-Tetrahydro-2H-Indeno[5,4-b]furan-8-ylidene)acetonitrile (CAS: 935-56-8) is an intermediate of Ramelteon (CAS: 196597-26-9). Ramelteon (TAK-375) is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively. The melatonin molecule wasmodified mainly by replacing the nitrogen of the indole ringwith a carbon to give an indane ring and by incorporating 5-methoxyl group in the indole ring into a more rigid furan ring. The selectivity of the resulting ramelteon for MT1 receptor iseight times more than that of MT2 receptor. Unlike melatonin,it is more effective in initiating sleep (MT1 activity)rather than to readjust the circadian rhythm (MT2 activity). Itappears to be distinctly more efficacious than melatonin butless efficacious than benzodiazepines as a hypnotic. Importantly, this drug has no addiction liability (it is not acontrolled substance). As a result, it has recently been approvedfor the treatment of insomnia.
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